Abstract
Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the "opened" form (OF) of DAE-TPE NPs was converted to the "closed" form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Ethylenes / chemistry*
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Ethylenes / pharmacology
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Fluorescence Resonance Energy Transfer
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HeLa Cells
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Humans
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Light
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Molecular Conformation
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Nanoparticles / chemistry*
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Photochemotherapy
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacology
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Reactive Oxygen Species / metabolism
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Stilbenes / chemistry*
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Thiophenes / chemistry
Substances
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Antineoplastic Agents
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Ethylenes
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Photosensitizing Agents
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Reactive Oxygen Species
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Stilbenes
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Thiophenes
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tetraphenylethylene
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benzothiophene
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ethylene