Determination of atropine in plasma by a direct radioreceptor assay

Pharm Weekbl Sci. 1987 Dec 11;9(6):321-3. doi: 10.1007/BF01956512.

Abstract

A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs.

MeSH terms

  • Animals
  • Atropine / blood*
  • Atropine / pharmacokinetics
  • Bronchi
  • Injections, Intravenous
  • Instillation, Drug
  • Radioligand Assay / methods*
  • Swine

Substances

  • Atropine