Multiple Tumor-Associated Intracranial Aneurysms Adjacent to a Suprasellar Germ Cell Tumor: Case Report and Review of Literature

Pediatr Neurosurg. 2021;56(5):482-491. doi: 10.1159/000517890. Epub 2021 Jul 28.


Introduction: Tumor-associated intracranial aneurysms are rare and not well understood.

Case presentation: We describe a 4-year-old female with multiple intracranial aneurysms intimately associated with a suprasellar germ cell tumor (GCT). We provide the clinical history, medical, and surgical treatment course, as well as a comprehensive and concise synthesis of the literature on tumor-associated aneurysms.

Discussion: We discuss mechanisms for aneurysm formation with relevance to the current case, including cellular and paracrine signaling pertinent to suprasellar GCTs and possible molecular pathways involved. We review the complex multidisciplinary treatment required for complex tumor and cerebrovascular interactions.

Keywords: Brain neoplasm; Intracranial aneurysm; Neuro-oncology; Suprasellar germ cell tumor; Tumor-associated aneurysm.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child, Preschool
  • Female
  • Humans
  • Intracranial Aneurysm* / diagnostic imaging
  • Intracranial Aneurysm* / etiology
  • Intracranial Aneurysm* / surgery
  • Neoplasms, Germ Cell and Embryonal* / diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal* / surgery
  • Pituitary Neoplasms*