Mood swings associated with the 'on-off' phenomenon in Parkinson's disease

Psychol Med. 1987 Nov;17(4):899-904. doi: 10.1017/s0033291700000702.


Mood swings accompanying the motor fluctuations of patients with Parkinson's disease on chronic levodopa treatment frequently occur, but are poorly recognized. Occasionally, their functional impact may be greater than that caused by the motor disability itself. In this study we have assessed the nature of, and relationship between, mood and motor fluctuations in nine Parkinsonian patients with 'on-off' motor swings. The results of an additional questionnaire survey confirm that 'on-off' mood swings occur in approximately two thirds of patients with Parkinson's disease experiencing motor fluctuations on dopaminergic treatment. Aetiological and therapeutic implications are discussed.

MeSH terms

  • Adult
  • Aged
  • Antiparkinson Agents / adverse effects*
  • Antiparkinson Agents / therapeutic use
  • Carbidopa / adverse effects*
  • Carbidopa / therapeutic use
  • Depressive Disorder / chemically induced
  • Drug Combinations / adverse effects
  • Drug Combinations / therapeutic use
  • Female
  • Humans
  • Levodopa / adverse effects*
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Mood Disorders / chemically induced*
  • Parkinson Disease / drug therapy*
  • Parkinson Disease, Secondary / chemically induced*


  • Antiparkinson Agents
  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa