Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats

J Diabetes Complications. 2021 Oct;35(10):107994. doi: 10.1016/j.jdiacomp.2021.107994. Epub 2021 Jul 15.


Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

Keywords: Diabetes; Hypoglycemia; Leptin; Leptin receptors; Zucker rats.