Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination

World J Gastroenterol. 2021 Jul 14;27(26):4004-4017. doi: 10.3748/wjg.v27.i26.4004.

Abstract

Chronic viral hepatitis is a significant health problem throughout the world, which already represents high annual mortality. By 2040, chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria, vitellogenesis-inhibiting hormone, and tuberculosis altogether. In this review, we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups, the goals set by the World Health Organization for the year 2030, and the key points to achieve them, such as timely access to antiviral treatment of direct-acting antiviral, which represents the key to achieving hepatitis C virus elimination. Likewise, we review the strategies to prevent transmission and achieve control of hepatitis B virus. Finally, we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs.

Keywords: Direct antiviral agents; Elimination program; Hepatitis B; Hepatitis C; Telemedicine; Vaccination.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • COVID-19*
  • Hepatitis B, Chronic* / diagnosis
  • Hepatitis B, Chronic* / drug therapy
  • Hepatitis B, Chronic* / epidemiology
  • Hepatitis C, Chronic* / diagnosis
  • Hepatitis C, Chronic* / drug therapy
  • Hepatitis C, Chronic* / epidemiology
  • Hepatitis, Viral, Human* / diagnosis
  • Hepatitis, Viral, Human* / drug therapy
  • Hepatitis, Viral, Human* / epidemiology
  • Humans
  • Liver Neoplasms* / drug therapy
  • Liver Neoplasms* / epidemiology
  • Liver Neoplasms* / prevention & control

Substances

  • Antiviral Agents