Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders

Mol Biol Rep. 2021 Aug;48(8):6131-6143. doi: 10.1007/s11033-021-06585-6. Epub 2021 Jul 29.

Abstract

In humans, the cytoplasmic FMR1 interacting protein (CYFIP) family is composed of CYFIP1 and CYFIP2. Despite their high similarity and shared interaction with many partners, CYFIP1 and CYFIP2 act at different points in cellular processes. CYFIP1 and CYFIP2 have different expression levels in human tissues, and knockout animals die at different time points of development. CYFIP1, similar to CYFIP2, acts in the WAVE regulatory complex (WRC) and plays a role in actin dynamics through the activation of the Arp2/3 complex and in a posttranscriptional regulatory complex with the fragile X mental retardation protein (FMRP). Previous reports have shown that CYFIP1 and CYFIP2 may play roles in posttranscriptional regulation in different ways. While CYFIP1 is involved in translation initiation via the 5'UTR, CYFIP2 may regulate mRNA expression via the 3'UTR. In addition, this CYFIP protein family is involved in neural development and maturation as well as in different neural disorders, such as intellectual disabilities, autistic spectrum disorders, and Alzheimer's disease. In this review, we map diverse studies regarding the functions, regulation, and implications of CYFIP proteins in a series of molecular pathways. We also highlight mutations and their structural effects both in functional studies and in neural diseases.

Keywords: Cytoplasmic FMR1 interacting protein; Neural development; Neural disorders; WAVE regulatory complex.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Adaptor Proteins, Signal Transducing / physiology*
  • Carrier Proteins / metabolism
  • Cytoplasm / metabolism
  • Cytosol / metabolism
  • Fragile X Mental Retardation Protein / genetics
  • Fragile X Mental Retardation Protein / physiology
  • Humans
  • Neurodegenerative Diseases / genetics*
  • Neurodegenerative Diseases / physiopathology
  • Neurogenesis
  • Neurons / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • CYFIP1 protein, human
  • CYFIP2 protein, human
  • Carrier Proteins
  • FMR1 protein, human
  • Fragile X Mental Retardation Protein

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