A 58-year-old man with B-cell chronic lymphocytic leukemia and multiple strokes

Francesca Magrinelli; Sara Mariotto; Gianpaolo Nadali; Giuseppe Todeschini; Massimiliano Lanzafame; Tiziana Cavallaro; Salvatore Monaco; Sergio Ferrari

doi:10.1111/bpa.13004

A 58-year-old man with B-cell chronic lymphocytic leukemia and multiple strokes

Brain Pathol. 2021 Nov;31(6):e13004. doi: 10.1111/bpa.13004. Epub 2021 Jul 30.

Authors

Francesca Magrinelli¹, Sara Mariotto¹, Gianpaolo Nadali², Giuseppe Todeschini², Massimiliano Lanzafame³, Tiziana Cavallaro¹, Salvatore Monaco¹, Sergio Ferrari¹

Affiliations

¹ Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
² Department of Medicine, University of Verona, Verona, Italy.
³ Department of Diagnostic and Public Health, University of Verona, Verona, Italy.

Abstract

A 58-year-old male with B-cell chronic lymphocytic leukemia presented with fever, chest pain, and acute-onset neurological deficits suggestive of multiple strokes (A). Brain autopsy revealed softening areas in the brain parenchyma (B, C) corresponding to extensive necrosis (D) caused by neuroinvasion by Aspergillus hyphae (E, F) necrosis (D) caused by neuroinvasion by Aspergillus hyphae (E, F).

Keywords: Aspergillosis; brain; immunodeficiency; mycosis; neuropathology.

Publication types

Case Reports

MeSH terms

Brain / diagnostic imaging*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Leukemia, Lymphocytic, Chronic, B-Cell / diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Stroke / complications*
Stroke / diagnostic imaging
Tomography, X-Ray Computed