Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, developing new and promising strategies as well as safe and effective drugs for treatment of IBD has become an urgent demand for clinics. The imbalance of Th17/Treg is a crucial event for the development of IBD, and studies have verified that correcting the imbalance of Th17/Treg is an effective strategy for preventing and treating IBD. Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.

Keywords: Action mechanism; Alpinetin (PubChem CID: 154279); Arctigenin (PubChem CID: 64981); Baicalin (PubChem CID: 64982); Berberine (PubChem CID: 2353); Cambogin (PubChem CID: 11135781); Curcumin (PubChem CID: 969516); Dihydroartemisinin (PubChem CID: 3000518); Epigallocatechin gallate (PubChem CID: 65064); Icariin (PubChem CID: 5318997); Indirubin (PubChem CID: 10177); Indole-3-carbinol (PubChem CID: 3712); Inflammatory bowel disease (IBD); Isoliquiritigenin (PubChem CID: 638278); Mangiferin (PubChem CID: 5281647); Naringenin (PubChem CID: 932); Norisoboldine (PubChem CID: 14539911); Paeoniflorin (PubChem CID: 442534); Phytochemicals; Resveratrol (PubChem CID: 445154); Tangeretin (PubChem CID: 68077); Tetrandrine (PubChem CID: 73078); Th17/Treg balance; Therapeutic effects; diindolylmethane (PubChem CID: 3071).