Scalable and accurate method for neuronal ensemble detection in spiking neural networks

PLoS One. 2021 Jul 30;16(7):e0251647. doi: 10.1371/journal.pone.0251647. eCollection 2021.

Abstract

We propose a novel, scalable, and accurate method for detecting neuronal ensembles from a population of spiking neurons. Our approach offers a simple yet powerful tool to study ensemble activity. It relies on clustering synchronous population activity (population vectors), allows the participation of neurons in different ensembles, has few parameters to tune and is computationally efficient. To validate the performance and generality of our method, we generated synthetic data, where we found that our method accurately detects neuronal ensembles for a wide range of simulation parameters. We found that our method outperforms current alternative methodologies. We used spike trains of retinal ganglion cells obtained from multi-electrode array recordings under a simple ON-OFF light stimulus to test our method. We found a consistent stimuli-evoked ensemble activity intermingled with spontaneously active ensembles and irregular activity. Our results suggest that the early visual system activity could be organized in distinguishable functional ensembles. We provide a Graphic User Interface, which facilitates the use of our method by the scientific community.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Electrodes
  • Models, Neurological
  • Nerve Net / physiology*
  • Principal Component Analysis
  • Retinal Ganglion Cells / cytology
  • Retinal Ganglion Cells / physiology*

Grants and funding

RH is funded by CONICYT scholarship CONICYT-PFCHA/Doctorado Nacional/2018- 21180428. (https://www.anid.cl) AM is funded by CONICYT scholarship CONICYT-PFCHA/Magíster Nacional/2020- 22200156. (https://www.anid.cl) RC is funded by Fondecyt Iniciación 2018 Proyecto 11181072. (https://www.anid.cl) MJE and AGP are funded by AFOSR Grant FA9550-19-1-0002 (https://www.afrl.af.mil/AFOSR/). AGP is funded by ICM-ANID #P09-022-F, CINV (http://www.iniciativamilenio.cl/). SM and JA received no funding for developing this work. All the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.