CD30L+ classical monocytes play a pro-inflammatory role in the development of ulcerative colitis in patients

Mol Immunol. 2021 Oct;138:10-19. doi: 10.1016/j.molimm.2021.06.016. Epub 2021 Jul 28.

Abstract

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that affects the large intestine and exhibits a relapsing and remitting course. It is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Although our previous studies have indicated that CD30L is involved in the adaptive immune response in UC, it remains unclear whether it participates in the innate immune response. Our results revealed that the CD30L level significantly increased in the circulating classical monocytes of patients with UC and showed a positive correlation with the severity of UC. CD30L may participate in monocyte-mediated inflammation in patients with UC through the activation of circulating classical monocytes. The present study provides insights into a marker of severity and a potential target for the development of immunological therapy of UC.

Keywords: CD30 ligand; Monocytes; Proinflammation; Ulcerative colitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • CD30 Ligand / immunology*
  • Colitis, Ulcerative / immunology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Monocytes / immunology*

Substances

  • CD30 Ligand
  • TNFSF8 protein, human