Superselective vesical artery embolization versus intravesical formalin for intractable hematuria in patients with bladder cancer

G Sonmez; S Tolga Tombul; N Herdem; T Demirtas; A Tatlısen; A Demirtas

doi:10.1016/j.acuro.2020.11.009

Superselective vesical artery embolization versus intravesical formalin for intractable hematuria in patients with bladder cancer

Actas Urol Esp (Engl Ed). 2021 Jul 28:S0210-4806(21)00121-2. doi: 10.1016/j.acuro.2020.11.009. Online ahead of print.

[Article in English, Spanish]

Authors

G Sonmez¹, S Tolga Tombul¹, N Herdem², T Demirtas³, A Tatlısen¹, A Demirtas⁴

Affiliations

¹ Department of Urology, Erciyes University, Kayseri, Turquía.
² Department of Radiology, Erciyes University, Kayseri, Turquía.
³ Department of Medical History and Ethics, Erciyes University, Kayseri, Turquía.
⁴ Department of Urology, Erciyes University, Kayseri, Turquía. Electronic address: mesane@gmail.com.

PMID: 34332813
DOI: 10.1016/j.acuro.2020.11.009

Abstract

Objective: Intractable hematuria is a leading critical problem occurring in patients with advanced stage bladder cancer (BCa) that are not suitable for radical cystectomy. The present study, for the first time in the literature, aimed to compare the effectiveness of intravesical formalin (IF) and superselective vesical artery embolization (SVAE) in the management of intractable and life-threatening hematuria in BCa patients.

Methods: The retrospective study included 40 BCa patients who underwent SVAE or IF treatment due to intractable hematuria after failure of other methods. Patients were divided into two groups based on the procedures administered: SVEA Group (n=24) and IF Group (n=16).

Results: The success rate at first-line therapy was 50% (12/24) in SVAE Group and 82% (13/16) in IF Group (p=0.046). Based on the success rates at first- and second-line therapies, the overall success rate in SVAE Group was 75% and this rate was similar to that of IF Group (p=0.439). Complication rate was significantly higher in IF patients than in SVAE patients (37.5% vs. 8.3; p=0.024), whereas duration of postoperative hospital stay was significantly longer in SVAE Group (15.8 vs. 6 days; p=0.041).

Conclusion: The advantages of IF appear to include shorter postoperative hospital stays and higher success rates at a single session, while the advantages of SVAE seem to include non-requirement of spinal/general anesthesia, easy repeatability, and low complication rates. In the management of patients with intractable hematuria, patients' general condition, comorbidities, and anesthesia-related risks should be taken into consideration.

Keywords: Bladder cancer; Cáncer de vejiga; Embolización; Embolization; Formalin; Formalina; Hematuria.