Renal and metabolic effects of SGLT-2i and DPP-4i according to basal estimated glomerular filtration rate: Analysis from GIOIA, an observational prospective study

Diabetes Res Clin Pract. 2021 Aug:178:108990. doi: 10.1016/j.diabres.2021.108990. Epub 2021 Jul 29.

Abstract

In the GIOIA study, users of both SGLT-2i and DPP-4i improved glycometabolic control, after 12 months, independently from baseline eGFR levels. Moreover, both classes led to a significant decrease in eGFR in participants with eGFR ≥ 90 ml/min/1.73 m2 and no deterioration in case of mild impairment of renal function.

Keywords: DPP-4i; Kidney function; SGLT-2i; Type 2 diabetes; eGFR.

Publication types

  • Observational Study

MeSH terms

  • Diabetes Mellitus, Type 2* / drug therapy
  • Dipeptidyl-Peptidase IV Inhibitors*
  • Glomerular Filtration Rate
  • Humans
  • Kidney / physiology
  • Prospective Studies
  • Sodium-Glucose Transporter 2 Inhibitors*

Substances

  • Dipeptidyl-Peptidase IV Inhibitors
  • Sodium-Glucose Transporter 2 Inhibitors