[Age-dependent changes in the DNA-polymerase activity of nuclei and mitochondria of the regenerating rat liver]

Ukr Biokhim Zh (1978). 1987 Nov-Dec;59(6):67-70.
[Article in Russian]


The DNA polymerase activity in nuclei and mitochondria of adult and old rat liver was determined. No age-dependent changes in the DNA polymerase activity have been found in the intact rat liver. On the contrary, after partial hepatectomy the DNA polymerase activity was higher in nuclei of the adult rat liver and in mitochondria of the old one. These peculiarities of the DNA polymerase activity with ageing may depend on changes in molecular properties of DNA polymerases, their synthesis and intracellular concentration.

MeSH terms

  • Aging / metabolism*
  • Animals
  • Cell Nucleus / enzymology
  • DNA Polymerase I / metabolism
  • DNA Polymerase II / metabolism*
  • DNA Replication
  • Kinetics
  • Liver Regeneration*
  • Mitochondria, Liver / enzymology*
  • Rats
  • Rats, Inbred Strains


  • DNA Polymerase I
  • DNA Polymerase II