Less is more: A novel single-tablet regimen with two-drugs, dolutegravir/lamivudine

Drug Discov Ther. 2021 Sep 22;15(4):225-226. doi: 10.5582/ddt.2021.01068. Epub 2021 Aug 1.


Combined antiretroviral therapy (cART) has significantly reduced human immunodeficiency virus (HIV) associated morbidity and mortality and turned HIV infection into a manageable chronic condition. However, lifelong cART is still required. Two-drug regimens could reduce the number of HIV agents and lower the adverse events caused by lifelong medication. A new two-drug regimen, DEVATO, consisting of dolutegravir and lamivudine has durable efficacy, is well-tolerated, and has a high barrier to viral resistance, which is why it is recommended as a new first-line treatment option for people living with HIV infection.

Keywords: HIV infection; dolutegravir/lamivudine; two-drug regimen.