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Review
. 2021 Jul 14:2021:9990020.
doi: 10.1155/2021/9990020. eCollection 2021.

The Combination of Tradition and Future: Data-Driven Natural-Product-Based Treatments for Parkinson's Disease

Zhijun Miao  1   2 , Jinwei Bai  3 , Li Shen  1 , Rajeev K Singla  1   4
Affiliations
Review

The Combination of Tradition and Future: Data-Driven Natural-Product-Based Treatments for Parkinson's Disease

Zhijun Miao et al. Evid Based Complement Alternat Med. .

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder in elderly people. The personalized diagnosis and treatment remain challenges all over the world. In recent years, natural products are becoming potential therapies for many complex diseases due to their stability and low drug resistance. With the development of informatics technologies, data-driven natural product discovery and healthcare is becoming reality. For PD, however, the relevant research and tools for natural products are quite limited. Here in this review, we summarize current available databases, tools, and models for general natural product discovery and synthesis. These useful resources could be used and integrated for future PD-specific natural product investigations. At the same time, the challenges and opportunities for future natural-product-based PD care will also be discussed.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
“5V” characteristics of big data.
Figure 2
Figure 2
The Monte Carlo tree search algorithm for synthesis route design.
Figure 3
Figure 3
A systemic structure of data-driven PD care.
See this image and copyright information in PMC

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References

    1. Schneider R. B., Iourinets J., Richard I. H. Parkinson’s disease psychosis: presentation, diagnosis and management. Neurodegenerative Disease Management. 2017;7(6):365–376. doi: 10.2217/nmt-2017-0028. - DOI - PubMed
    1. Kline E. M., Houser M. C., Herrick M. K., et al. Genetic and environmental factors in Parkinson’s disease converge on immune function and inflammation. Movement Disorders. 2021;36(1):25–36. doi: 10.1002/mds.28411. - DOI - PMC - PubMed
    1. Elfil M., Kamel S., Kandil M., Koo B. B., Schaefer S. M. Implications of the gut microbiome in Parkinson’s disease. Movement Disorders. 2020;35(6):921–933. doi: 10.1002/mds.28004. - DOI - PubMed
    1. Marras C., Canning C. G., Goldman S. M. Environment, lifestyle, and Parkinson’s disease: implications for prevention in the next decade. Movement Disorders. 2019;34(6):801–811. doi: 10.1002/mds.27720. - DOI - PubMed
    1. Spanaki C., Boura I., Avgoustaki A., et al. Buried bumper syndrome: a common complication of levodopa intestinal infusion for Parkinson disease. Parkinsonism & Related Disorders. 2021;85:59–62. doi: 10.1016/j.parkreldis.2021.02.032. - DOI - PubMed

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