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. 2021 Oct;174(10):1483-1487.
doi: 10.7326/M21-1375. Epub 2021 Jul 20.

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study

Ashley Kieran Clift  1 , Defne Saatci  1 , Carol A C Coupland  2 , Hajira Dambha-Miller  3 , Julia Hippisley-Cox  1 ; International Investigator Group for Ethnicity and COVID-19
Collaborators, Affiliations

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study

Ashley Kieran Clift et al. Ann Intern Med. 2021 Oct.
No abstract available

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Conflict of interest statement

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-1375.

Figures

Figure.
Figure.. Adjusted HRs with 95% CIs for the observed associations between sickle cell disease and sickle cell trait with COVID-19–related hospitalization and COVID-19–related death; the reference group is persons without any sickle cell disorder.
Cause-specific Cox regression models were stratified by individual general practice and adjusted for age (restricted cubic spline with 5 knots), sex, and self-reported ethnicity (White, South Asian, Black, and other [including Chinese, multiracial, and Arab]). We did post hoc analyses restricted to those with sickle cell disorders. For COVID-19–related hospitalization, compared with persons with sickle cell trait, those with sickle cell disease had an adjusted HR of 3.00 (95% CI, 1.99 to 4.52). For COVID-19–related death, persons with sickle cell disease had an adjusted HR of 1.37 (CI, 0.62 to 3.02) compared with those with sickle cell trait. HR = hazard ratio.
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