Sleep and circadian rhythms: pillars of health-a Keystone Symposia report

Ann N Y Acad Sci. 2021 Dec;1506(1):18-34. doi: 10.1111/nyas.14661. Epub 2021 Aug 2.


The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock. This misalignment can disrupt and impair physiological and psychological parameters that may ultimately put people at higher risk for chronic diseases like cancer, cardiovascular disease, and other metabolic disorders. Understanding the mechanisms that regulate sleep circadian rhythms may ultimately lead to insights on behavioral interventions that can lower the risk of these diseases. On February 25, 2021, experts in sleep, circadian rhythms, and chronobiology met virtually for the Keystone eSymposium "Sleep & Circadian Rhythms: Pillars of Health" to discuss the latest research for understanding the bidirectional relationships between sleep, circadian rhythms, and health and disease.

Keywords: appetite control; biomarkers; circadian misalignment; circadian rhythm; food timing; shift work; sleep; sleep duration; sleep homeostasis; social jetlag.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / psychology
  • Circadian Clocks / physiology
  • Circadian Rhythm / physiology*
  • Congresses as Topic / trends*
  • Humans
  • Meals / physiology*
  • Meals / psychology
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Neoplasms / psychology
  • Research Report*
  • Risk Factors
  • Sleep / physiology*