Objective: To evaluate the safety, efficacy and feasibility of transoral robotic surgery (TORS) for parapharyngeal space (PPS) neoplasms. Methods: We collected data from 7 patients with PPS neoplasm who received TORS in Sun Yat-sen University Cancer Center between May 2017 and November 2020, and patients' clinical and pathological characteristics were analysed. There were 2 men and 5 women with age ranged from 35 to 76 years. Among them, 2 patients underwent secondary surgery, 2 patients required combined transcervical approach to complete surgery, and 1 patient was suspected of ipsilateral cervical lymph node metastasis and scheduled for diagnostic TORS. The preoperative tumor size, operation time, intraoperative blood loss, postoperative bleeding, dyspnea, neurological impairment, feeding time and postoperative hospital stay were analyzed. SPSS 24.0 was used to analyze the data. Results: TORS was performed successfully with complete removal of tumors in all 7 cases. Among 6 patients with curative TORS, 5 patients received TORS with postoperative diagnoses of neurogenic tumors and 1 patient underwent TORS combined transcervical approach with postoperative disgnosis of recurrent pleomorphic adenoma; no intraoperative tumor rupture occurred; the intraoperative blood loss was 20-200 ml with a median of 40 ml; the operation time was 65.0-238.0 min with a median of 77.5 min; the oral feeding time was 3-6 days with a median of 3 days; and the postoperative hospital stay was 4.2±1.6 days. One patient presented with neck swelling 3 days after surgery, but this symptom relieved 3 days later after treatments with antibiotic, hemostasis and detumescence. One patient received diagnostic TORS, as intraoperative pathology indicating a recurrent pleomorphic adenoma, then the neoplasm got completely resected through transcervical-transparotid approach. None of 7 patients manifested with airway obstruction, bleeding or nerve injury symptoms after operation. All patients were followed for 2 to 44 months, no local recurrence or distant metastasis was found. Conclusions: TORS is a safe, effective and feasible treatment for selected PPS neoplasms, with less cosmetic impact, less trauma and blood loss, few postoperative complications, enhanced postoperative recovery and short hospital stay.
目的： 对经口机器人手术（transoral robotic surgery，TORS）治疗咽旁间隙肿瘤这一方法的效果及可行性进行评估。 方法： 回顾性分析2017年5月至2020年11月中山大学肿瘤防治中心头颈科收治的7例行TORS治疗咽旁间隙肿瘤患者的临床病例资料，男2例，女5例，年龄35～76岁。其中二次手术者2例次，需联合经颈入路完成手术者2例次，怀疑同侧颈部淋巴结转移拟行诊断性目的TORS者1例次。分析患者的肿瘤大小、手术时间、术中出血量，以及术后局部有无出血、呼吸困难、神经功能损伤、经口进食时间等各项指标。应用SPSS 24.0软件对数据进行统计学分析。 结果： 7例患者均顺利完成手术，肿瘤完整切除、无破裂。6例行治愈性TORS，包括5例全程TORS，病理为神经鞘瘤；1例TORS术中联合经颈入路手术，冰冻病理为多形性腺瘤术后复发。此6例患者的术中出血量为20～200 ml，中位数为40 ml；手术时长为65.0～238.0 min，中位时长77.5 min；术后经口进食时间为3～6 d，中位时间3 d；术后住院时间为（4.2±1.6）d。1例患者术后第3天出现颈部肿胀，经抗感染、止血、消肿对症处理3 d后症状缓解。1例行诊断性TORS的病例，术中病理提示为多形性腺瘤术后复发，联合经颈入路行腮腺全切除术。7例患者术后未发现气道梗阻、大出血、颅神经受损等症状。随访2～44个月，所有患者均未出现复发转移征象。 结论： TORS治疗咽旁间隙肿瘤具有外观影响小、安全、高效等特点，对于符合适应证的咽旁间隙肿瘤是很好的手术方式。.