Progression of SARS-CoV-2 Seroprevalence in St. Louis, Missouri, through January 2021

mSphere. 2021 Aug 25;6(4):e0045021. doi: 10.1128/mSphere.00450-21. Epub 2021 Aug 4.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity was assessed for 3,066 individuals visiting hospitals in St. Louis, Missouri, during July 2020, November 2020, or January 2021. Seropositivity in children increased from 5.22% in July to 21.16% in January. In the same time frame, seropositivity among adults increased from 4.52% to 19.03%, prior to initiation of mass vaccination. IMPORTANCE This study determined the percentage of children and adult samples from the St. Louis metropolitan area in Missouri with SARS-CoV-2 antibodies during three collection periods spanning July 2020 to January 2021. By January 2021, 20.68% of the tested individuals had antibodies. These results show the evolution of the SARS-CoV-2 pandemic in St. Louis, Missouri, and provide a snapshot of the extent of infection just prior to the start of mass vaccination.

Keywords: COVID-19; ELISA; SARS-CoV-2; serology; seroprevalence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / immunology
  • COVID-19 / immunology*
  • COVID-19 Serological Testing / methods
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Missouri
  • Pandemics / prevention & control
  • SARS-CoV-2 / immunology*
  • Seroepidemiologic Studies
  • Young Adult


  • Antibodies, Viral