Age-Related Macular Degeneration

N Engl J Med. 2021 Aug 5;385(6):539-547. doi: 10.1056/NEJMcp2102061.


A 78-year-old woman presents with vision changes in the right eye for one week. Specifically, she describes central blurring in her vision and bending or waviness in straight lines. She also reports increasing difficulty reading print and often feels that there are blind spots in her vision. How would you diagnose and treat this patient?

Publication types

  • Review

MeSH terms

  • Aged
  • Dietary Supplements
  • Female
  • Humans
  • Macular Degeneration* / diagnosis
  • Macular Degeneration* / drug therapy
  • Patient Education as Topic
  • Practice Guidelines as Topic
  • Retina / diagnostic imaging
  • Retina / pathology
  • Retinal Drusen
  • Severity of Illness Index
  • Slit Lamp Microscopy
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors


  • Vascular Endothelial Growth Factor A