CD36 pumps fat to defang killer T cells in tumors

Manikandan Subramanian; Federica M Marelli-Berg

doi:10.1016/j.cmet.2021.07.004

CD36 pumps fat to defang killer T cells in tumors

Cell Metab. 2021 Aug 3;33(8):1509-1511. doi: 10.1016/j.cmet.2021.07.004.

Authors

Manikandan Subramanian¹, Federica M Marelli-Berg²

Affiliations

¹ Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: m.subramanian@qmul.ac.uk.
² Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: f.marelli-berg@qmul.ac.uk.

PMID: 34348095
DOI: 10.1016/j.cmet.2021.07.004

Abstract

The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD36 Antigens
CD8-Positive T-Lymphocytes
Ferroptosis*
Humans
Neoplasms*
Tumor Microenvironment

Substances

CD36 Antigens

Abstract

Publication types

MeSH terms

Substances

Grants and funding