Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease

Dong Wang; Fanglian Chen; Zhaoli Han; Zhenyu Yin; Xintong Ge; Ping Lei

doi:10.3389/fncel.2021.695479

Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease

Front Cell Neurosci. 2021 Jul 19:15:695479. doi: 10.3389/fncel.2021.695479. eCollection 2021.

Authors

Dong Wang^{1

2}, Fanglian Chen³, Zhaoli Han^{1

2}, Zhenyu Yin^{1

2}, Xintong Ge^{3

4}, Ping Lei^{1

2}

Affiliations

¹ Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
² Tianjin Geriatrics Institute, Tianjin, China.
³ Tianjin Neurological Institute, Tianjin, China.
⁴ Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.

Abstract

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood-brain barrier. However, the BBB is also crucial in maintaining the normal metabolism of Aβ, and dysfunction of the BBB aggravates Aβ deposition. This review characterizes Aβ deposition and BBB damage in AD, summarizes their interactions, and details their respective mechanisms.

Keywords: Alzheimer’s disease; P-glycoprotein; amyloid-β; blood–brain barrier; low-density lipoprotein receptor-related protein 1; receptor for advanced glycation end products.

Publication types

Review