Alzheimer-related neuronal protein A68: specificity and distribution

Ann Neurol. 1987 Oct;22(4):521-6. doi: 10.1002/ana.410220412.

Abstract

We previously reported that the monoclonal antibody Alz-50 recognizes a protein (A68) with an apparent molecular weight of 68,000 daltons in the brains of patients who died with Alzheimer's disease, but not in brain tissue from individuals free of neurological disease. We now report that substantial quantities of this protein are found in brain tissue only from patients with Alzheimer's disease. Although trace amounts of A68 may be detected in cases of Guam-Parkinson dementia complex and Pick's disease, accumulation of A68 in neuronal perikarya and particularly in neuronal processes appears to be a unique feature of Alzheimer's disease. A68 can readily be detected in cerebrospinal fluid after concentration and partial purification. These data, combined with the quantitation of immunoreactivity in other neurological diseases, suggest the usefulness of detection of A68 in cerebrospinal fluid for diagnosis of Alzheimer's disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / cerebrospinal fluid
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / immunology
  • Brain Chemistry*
  • Dementia / cerebrospinal fluid
  • Dementia / diagnosis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / analysis*
  • Nerve Tissue Proteins / cerebrospinal fluid
  • Parkinson Disease / cerebrospinal fluid
  • Parkinson Disease / diagnosis
  • tau Proteins

Substances

  • MAPT protein, human
  • Nerve Tissue Proteins
  • tau Proteins