Central motor conduction in motor neuron disease

Ann Neurol. 1987 Oct;22(4):544-6. doi: 10.1002/ana.410220417.


Central motor conduction was assessed in 13 patients with motor neuron disease and in 15 control subjects. All patients with motor neuron disease, even those without clinical pyramidal signs, had slowed central motor conduction, and in some the delays were asymmetrical. Evoked motor potentials represent a new and reliable method to detect physiological abnormalities of central motor pathways early in the course of motor neuron disease.

MeSH terms

  • Action Potentials
  • Adult
  • Aged
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Electric Stimulation
  • Humans
  • Middle Aged
  • Motor Neurons / physiopathology*
  • Neural Conduction*
  • Neuromuscular Diseases / physiopathology*