Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen

Ann Neurol. 1987 Oct;22(4):546-50. doi: 10.1002/ana.410220418.


High-field strength (1.5 Tesla) magnetic resonance imaging in 15 patients with multiple and extensive white-matter lesions and clinically definite multiple sclerosis delineated a previously undescribed finding of abnormally decreased signal intensity on T2-weighted images in the thalamus and putamen. The decreased signal intensity (preferential decreased T2 relaxation time) is most likely to be related to abnormally increased iron accumulation causing local magnetic field heterogeneities.

MeSH terms

  • Humans
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / diagnosis*
  • Putamen / pathology*
  • Thalamus / pathology*