Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis

Sci Rep. 2021 Aug 5;11(1):15881. doi: 10.1038/s41598-021-94464-2.


Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animal Feed / adverse effects
  • Animal Feed / analysis
  • Animal Nutritional Physiological Phenomena
  • Animals
  • Cardiomyopathy, Dilated / etiology*
  • Cardiomyopathy, Dilated / metabolism*
  • Cardiomyopathy, Dilated / veterinary
  • Diet / adverse effects*
  • Diet / veterinary
  • Dog Diseases / etiology
  • Dogs
  • Echocardiography
  • Lens Plant / metabolism
  • Metabolomics
  • Oryza / metabolism
  • Peas / metabolism