Diverse strategies for the efficient and attractive synthesis of a wide variety of relevant 1,4,5-trisubstituted 1,2,3-triazole molecules are reported. The synthesis of this category of diverse fully functionalized 1,2,3-triazoles has become a necessary and unique research subject in modern synthetic organic key transformations in academia, pharmacy, and industry. The current review aims to cover a wide literature survey of numerous synthetic strategies. Recent reports (2017-2021) in the field of 1,4,5-trisubstituted 1,2,3-triazoles are emphasized in this current review.
Keywords: 1,4,5-trisubstituted 1,2,3-triazoles; Click reaction; N-containing heterocycles; [3 + 2]‐cycloaddition; azides; fully functionalized 1,2,3-triazoles.
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