Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021

Brechje de Gier; Stijn Andeweg; Rosa Joosten; Ronald Ter Schegget; Naomi Smorenburg; Jan van de Kassteele; RIVM COVID-19 surveillance and epidemiology team 1,; Susan Jm Hahné; Susan van den Hof; Hester E de Melker; Mirjam J Knol; Members of the RIVM COVID-19 surveillance and epidemiology team

doi:10.2807/1560-7917.ES.2021.26.31.2100640

Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021

Euro Surveill. 2021 Aug;26(31):2100640. doi: 10.2807/1560-7917.ES.2021.26.31.2100640.

Collaborators

Agnetha Hofhuis, Anne Teirlinck, Alies van Lier, Bronke Boudewijns, Carolien Verstraten, Guido Willekens, Irene Veldhuijzen, Jan Polman, Jan van de Kassteele, Jeroen Alblas, Janneke van Heereveld, Janneke Heijne, Kirsten Bulsink, Lieke Wielders, Liselotte van Asten, Liz Jenniskens, Loes Soetens, Maarten Mulder, Maarten Schipper, Marit de Lange, Naomi Smorenburg, Nienke Neppelenbroek, Patrick van den Berg, Priscila de Oliveira Bressane Lima, Rolina van Gaalen, Sara Wijburg, Senna van Iersel, Siméon de Bruijn, Stijn Andeweg, Sjoerd Wierenga, Susan Lanooij, Sylvia Keijser, Tara Smit, Don Klinkenberg, Jantien Backer, Pieter de Boer, Scott McDonald, Amber Maxwell, Annabel Niessen, Brechje de Gier, Danytza Berry, Daphne van Wees, Dimphey van Meijeren, Eric R A Vos, Frederika Dijkstra, Jeanet Kemmeren, Kylie Ainslie, Marit Middeldorp, Marjolein Kooijman, Mirjam Knol, Shahabeh Abbas Zadeh, Timor Faber, Albert Jan van Hoek, Eveline Geubbels, Hester de Melker, Jacco Wallinga, Rianne van Gageldonk-Lafeber, Susan Hahne, Susan van den Hof

Affiliations

¹ Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
² GGD Brabant Zuidoost, Eindhoven, the Netherlands.
³ The members of the group are listed under Investigators.

PMID: 34355689
PMCID: PMC8343550
DOI: 10.2807/1560-7917.ES.2021.26.31.2100640

Abstract

Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63-77).

Keywords: COVID-19; SARS-CoV-2; household study; transmission; vaccine effectiveness.

MeSH terms

COVID-19 Vaccines
COVID-19*
Family Characteristics
Humans
Netherlands / epidemiology
SARS-CoV-2*

Substances

COVID-19 Vaccines