Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Biomolecules. 2021 Jul 11;11(7):1015. doi: 10.3390/biom11071015.

Abstract

Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

Keywords: cancer therapy; dual enzyme; enzyme mimetic; nanomaterials; nanozymes; peroxidase mimetic; phototherapy; single atom; theranostics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomimetic Materials / pharmacology
  • Humans
  • Nanostructures / chemistry
  • Nanostructures / therapeutic use*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Oxygen
  • Peroxidase / chemistry*
  • Peroxidase / metabolism
  • Photochemotherapy / methods*
  • Tumor Hypoxia
  • Tumor Microenvironment

Substances

  • Peroxidase
  • Oxygen