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Review
. 2021 Oct:78:105686.
doi: 10.1016/j.ultsonch.2021.105686. Epub 2021 Jul 27.

Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review

Muhammad Faisal Manzoor  1 , Abid Hussain  2 , Aysha Sameen  3 , Amna Sahar  4 , Sipper Khan  5 , Rabia Siddique  6 , Rana Muhammad Aadil  3 , Bin Xu  7
Affiliations
Free PMC article
Review

Novel extraction, rapid assessment and bioavailability improvement of quercetin: A review

Muhammad Faisal Manzoor et al. Ultrason Sonochem. 2021 Oct.
Free PMC article

Abstract

Quercetin (QUR) have got the attention of scientific society frequently due to their wide range of potential applications. QUR has been the focal point for research in various fields, especially in food development. But, the QUR is highly unstable and can be interrupted by using conventional assessment methods. Therefore, researchers are focusing on novel extraction and non-invasive tools for the non-destructive assessment of QUR. The current review elaborates the different novel extraction (ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, and enzyme-assisted extraction) and non-destructive assessment techniques (fluorescence spectroscopy, terahertz spectroscopy, near-infrared spectroscopy, hyperspectral imaging, Raman spectroscopy, and surface-enhanced Raman spectroscopy) for the extraction and identification of QUR in agricultural products. The novel extraction approaches facilitate shorter extraction time, involve less organic solvent, and are environmentally friendly. While the non-destructive techniques are non-interruptive, label-free, reliable, accurate, and environmental friendly. The non-invasive spectroscopic and imaging methods are suitable for the sensitive detection of bioactive compounds than conventional techniques. QUR has potential therapeutic properties such as anti-obesity, anti-diabetes, antiallergic, antineoplastic agent, neuroprotector, antimicrobial, and antioxidant activities. Besides, due to the low bioavailability of QUR innovative drug delivery strategies (QUR loaded gel, QUR polymeric micelle, QUR nanoparticles, glucan-QUR conjugate, and QUR loaded mucoadhesive nanoemulsions) have been proposed to improve its bioavailability and providing novel therapeutic approaches.

Keywords: Bioavailability; Noninvasive assessment; Novel extraction; Quercetin.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
The normal RS and SERS peaks for QUR using 532, 633, 785, and 1064 nm excitation wavelengths lasers adopted from Dendisová, Palounek, Švecová and Prokopec .
Fig. 2
Fig. 2
Quercetin poor bioavailability reasons and improvement approaches.
Fig. 3
Fig. 3
Different kind of lipid formulations and drug-loaded liposomes.
See this image and copyright information in PMC

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References

    1. Batiha G.-S., Beshbishy A.M., Ikram M., Mulla Z.S., El-Hack M.E.A., Taha A.E., Algammal A.M., Elewa Y.H.A. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020;9(3):374. doi: 10.3390/foods9030374. - DOI - PMC - PubMed
    1. Bossolani G.D.P., Silva B.T., Perles J.V.C.M., Lima M.M., Frez F.C.V., de Souza S.R.G., Sehaber-Sierakowski C.C., Bersani-Amado C.A., Zanoni J.N. Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions. Life Sci. 2019;238:116956. - PubMed
    1. Kundur S., Prayag A., Selvakumar P., Nguyen H., McKee L., Cruz C., Srinivasan A., Shoyele S., Lakshmikuttyamma A. Synergistic anticancer action of quercetin and curcumin against triple-negative breast cancer cell lines. J. Cell. Physiol. 2019;234:11103–11118. - PubMed
    1. Caddeo C., Gabriele M., Fernàndez-Busquets X., Valenti D., Fadda A.M., Pucci L., Manconi M. Antioxidant activity of quercetin in Eudragit-coated liposomes for intestinal delivery. Int. J. Pharm. 2019;565:64–69. - PubMed
    1. Ding Y., Li C., Zhang Y., Ma P., Zhao T., Che D., Cao J., Wang J., Liu R., Zhang T. Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis. Food Chem. Toxicol. 2020;135:110924. - PubMed

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