Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke

Phytomedicine. 2021 Sep:90:153652. doi: 10.1016/j.phymed.2021.153652. Epub 2021 Jul 16.


Background: Ischemic stroke is a common cerebrovascular disease. Due to sudden interruption of blood flow by arterial thrombus, amounts of neurons in ischemic central and penumbral regions occur necrosis and apoptosis resulting in serious injury of neurological function. Chinese medicines have a great advantage in ischemic stroke treatment and recovery, especially Angelica sinensis.

Purpose: There are a large number of studies reported that Angelica injection and A. sinensis active compounds. We systematically reviewed the effects and mechanisms of A. sinensis in recent years according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements, and excavated its therapeutic potentiality for exploring more effective and safe compounds for ischemic stroke precision treatment.

Results: A. sinensis extracts and active compounds, such as Z-ligustilide, 3-n-Butylphthalide, and ferulic acid have significant effects of anti-inflammation, anti-oxidative stress, angiogenesis, neurogenesis, anti-platelet aggregation, anti-atherosclerosis, protection of vessels, which contributes to improvement of neurological function on ischemic stroke.

Conclusion: A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.

Keywords: Angelica sinensis; Ischemic Stroke; Mechanisms; Therapeutic effects.

Publication types

  • Systematic Review

MeSH terms

  • Angelica sinensis* / chemistry
  • Brain Ischemia* / drug therapy
  • Drugs, Chinese Herbal / therapeutic use*
  • Humans
  • Ischemic Stroke* / drug therapy


  • Drugs, Chinese Herbal
  • angelicae sinensis extract