Toward a better understanding of persistent headache after mild COVID-19: Three migraine-like yet distinct scenarios

Headache. 2021 Sep;61(8):1277-1280. doi: 10.1111/head.14197. Epub 2021 Aug 7.


One year after the outbreak of coronavirus disease 2019 (COVID-19), referrals for persistent headache, often defined as "post-COVID headache," have become increasingly common in outpatient headache clinics. However, it is important to take into consideration that this term may include a spectrum of clinically different headache types. We describe three cases of migraine-like headaches in individuals with a history of mild COVID-19 infection to demonstrate some of the different phenotypes of persistent headaches seen. These cases highlight the importance of a careful evaluation when assessing the complexities of "post-COVID headache" as well as the need to further investigate the different, underlying, pathophysiological mechanisms.

Keywords: SARS-CoV-2; headache; migraine; post-COVID-19.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19 / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / virology*
  • SARS-CoV-2

Supplementary concepts

  • post-acute COVID-19 syndrome