Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes

Nitish Khurana; Bhuvanesh Yathavan; Jolanta Jedrzkiewicz; Amarbir S Gill; Abigail Pulsipher; Jeremiah A Alt; Hamidreza Ghandehari

doi:10.1016/j.nano.2021.102453

Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes

Nanomedicine. 2021 Nov:38:102453. doi: 10.1016/j.nano.2021.102453. Epub 2021 Aug 4.

Authors

Nitish Khurana¹, Bhuvanesh Yathavan¹, Jolanta Jedrzkiewicz², Amarbir S Gill³, Abigail Pulsipher⁴, Jeremiah A Alt⁵, Hamidreza Ghandehari⁶

Affiliations

¹ Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA.
² Department of Pathology, University of Utah, Salt Lake City, UT, USA.
³ Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
⁴ Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
⁵ Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: Jeremiah.Alt@hsc.utah.edu.
⁶ Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: hamid.ghandehari@utah.edu.

Abstract

Chronic rhinosinusitis (CRS) is a debilitating inflammatory disorder of the sinonasal mucosa that substantially diminishes patient quality of life. Progress surrounding management of this disease has been crippled by a lack of therapeutic innovation. It has been posited that increased vascularity within the diseased sinuses of patients with CRS may allow for improved systemic drug delivery via nanoscale liposomal carriers. Such a system could enhance drug distribution, accumulation, and retention within the sinuses, ultimately leading to improved patient outcomes. PEGylated liposomes loaded with indocyanine green (ICG) were synthesized, characterized and systemically administered in a mouse model of CRS. Accumulation and retention of ICG in sinonasal tissue were evaluated. Compared to healthy controls, CRS mice showed significant sinonasal tissue accumulation and retention of PEGylated liposomal ICG for up to 21 days (P < 0.001). Conversely, free ICG was eliminated from the body after 24 h in both groups.

Keywords: Chronic rhinosinusitis; Inflammation; Liposomes; Nanocarriers; Vascular permeability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Capillary Permeability
Chronic Disease
Humans
Liposomes*
Mice
Polyethylene Glycols
Quality of Life
Sinusitis* / drug therapy

Substances

Liposomes
Polyethylene Glycols

Grants and funding

R01 CA227225/CA/NCI NIH HHS/United States