Preparation of ultra-long stable ovalbumin/sodium carboxymethylcellulose nanoparticle and loading properties of curcumin

Fuge Niu; Demei Hu; Feina Gu; Yixuan Du; Bin Zhang; Shuang Ma; Weichun Pan

doi:10.1016/j.carbpol.2021.118451

Preparation of ultra-long stable ovalbumin/sodium carboxymethylcellulose nanoparticle and loading properties of curcumin

Carbohydr Polym. 2021 Nov 1:271:118451. doi: 10.1016/j.carbpol.2021.118451. Epub 2021 Jul 16.

Authors

Fuge Niu¹, Demei Hu², Feina Gu², Yixuan Du², Bin Zhang², Shuang Ma², Weichun Pan³

Affiliations

¹ Food Safety Key Lab of Zhejiang Province, The School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China; Anhui Rongda Poultry Development Co., Ltd., Xuancheng 242200, China. Electronic address: niufg123@hotmail.com.
² Food Safety Key Lab of Zhejiang Province, The School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
³ Food Safety Key Lab of Zhejiang Province, The School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China. Electronic address: panweichun1@yahoo.com.

PMID: 34364584
DOI: 10.1016/j.carbpol.2021.118451

Abstract

OVA (ovalbumin)/CMC (sodium carboxymethylcellulose) nanoparticles are prepared by combining complex coacervation and thermal induction. The effect of different parameters on stability of OVA/CMC nanoparticles (different ratios, pH, temperature, salt concentration and storage time) is investigated. And then the loading and stabilizing mechanism of particles on curcumin are further analyzed. After heating, OVA and CMC in particle could further cross-linking and a highly salt-tolerant and ultra-long stable nanoparticle can be formed. OVA/CMC nanoparticle with the loose structure of wool ball could effectively load curcumin with the loading content and loading efficiency of 36.40 and 95.40%, 36.30 and 92.82%, 36.0 and 94.48% for the ratios of 1:2, 1:1 and 2:1, respectively. Curcumin-loaded of OVA/CMC nanoparticles show good DPPH· scavenging activity, Ferric-reducing ability and ABTS⁺ scavenging activity compared with curcumin/water. The results can be useful for designing food and beverage particle with improving bioactive substances functional properties.

Keywords: Antioxidant activity; Bioactive substances; Loading property; OVA/CMC nanoparticles; Stability.

MeSH terms

Carboxymethylcellulose Sodium / chemistry*
Curcumin / chemistry*
Drug Carriers / chemistry*
Drug Compounding / methods
Free Radical Scavengers / chemistry*
Hydrogen-Ion Concentration
Nanoparticles / chemistry*
Ovalbumin / chemistry*
Particle Size
Temperature

Substances

Drug Carriers
Free Radical Scavengers
Ovalbumin
Curcumin
Carboxymethylcellulose Sodium