Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Trends Neurosci. 2021 Sep;44(9):714-727. doi: 10.1016/j.tins.2021.06.007. Epub 2021 Aug 5.


Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association are not well understood. Senescent cells accumulate in aged tissues and have been shown to play causal roles in age-related pathologies through their proinflammatory secretome. The question arises whether senescence-induced inflammation might contribute to AD and bridge the gap between aging and AD. Here, we highlight the role of cellular senescence as a driver of the aging phenotype, and discuss the current evidence that connects senescence with AD and neurodegeneration.

Trial registration: ClinicalTrials.gov NCT04785300 NCT04685590.

Keywords: SASP; aging; astrocytes; microglia; neurodegeneration; neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Aging
  • Alzheimer Disease*
  • Cellular Senescence
  • Humans
  • Inflammation
  • Phenotype

Associated data

  • ClinicalTrials.gov/NCT04785300
  • ClinicalTrials.gov/NCT04685590