The CPNE Family and Their Role in Cancers

Haicheng Tang; Pei Pang; Zhu Qin; Zhangyan Zhao; Qingguo Wu; Shu Song; Feng Li

doi:10.3389/fgene.2021.689097

The CPNE Family and Their Role in Cancers

Front Genet. 2021 Jul 23:12:689097. doi: 10.3389/fgene.2021.689097. eCollection 2021.

Authors

Haicheng Tang¹, Pei Pang², Zhu Qin¹, Zhangyan Zhao¹, Qingguo Wu¹, Shu Song³, Feng Li¹

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
² Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
³ Department of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in cancer research and treatment, the overall prognosis of lung cancer patients remains poor. Therefore, the identification for novel therapeutic targets is critical for the diagnosis and treatment of lung cancer. CPNEs (copines) are a family of membrane-bound proteins that are highly conserved, soluble, ubiquitous, calcium dependent in a variety of eukaryotes. Emerging evidences have also indicated CPNE family members are involved in cancer development and progression as well. However, the expression patterns and clinical roles in cancer have not yet been well understood. In this review, we summarize recent advances concerning CPNE family members and provide insights into new potential mechanism involved in cancer development.

Keywords: cancer; copines; metastasis; proliferation; signaling pathway.

Publication types

Review