Case Report: Successful Chimeric Antigen Receptor T Cell Therapy in Haploidentical-Allogeneic Stem Cell Transplant Patients With Post-Transplant Lymphoproliferative Disorder

Nan Yan; Na Wang; Peiling Zhang; Gaoxiang Wang; Xia Mao; Dan Peng; Dong Kuang; Liting Chen; Li Zhu; Jianfeng Zhou; Yicheng Zhang; Yang Cao

doi:10.3389/fonc.2021.709370

Case Report: Successful Chimeric Antigen Receptor T Cell Therapy in Haploidentical-Allogeneic Stem Cell Transplant Patients With Post-Transplant Lymphoproliferative Disorder

Front Oncol. 2021 Jul 22:11:709370. doi: 10.3389/fonc.2021.709370. eCollection 2021.

Authors

Nan Yan¹, Na Wang^{1

2}, Peiling Zhang^{1

2}, Gaoxiang Wang^{1

2}, Xia Mao^{1

2}, Dan Peng³, Dong Kuang⁴, Liting Chen^{1

2}, Li Zhu^{1

2}, Jianfeng Zhou^{1

2}, Yicheng Zhang^{1

2}, Yang Cao^{1

2}

Affiliations

¹ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, China.
³ Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Background: Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (EBV-PTLD) is a potentially fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Rituximab has been proven to dramatically improve the prognosis of patients with EBV reactivation and PTLD. However, reports on the curative management of refractory PTLD are scarce.

Case presentation: In this report, we describe the successful management of two patients with EBV-PTLD with chimeric antigen receptor T-cell (CAR-T) therapy.

Conclusion: The present results demonstrated that patients with EBV-PTLD may benefit from CAR-T therapy and that the toxicity is manageable. Further studies are needed to verify these findings.

Keywords: ALL; CAR-T; EBV; HSCT; PTLD.

Publication types

Case Reports