Combination of hyaluronic acid fillers and personalized skincare as a perfect tool in aesthetic medicine

Dermatol Ther. 2021 Sep;34(5):e15092. doi: 10.1111/dth.15092. Epub 2021 Aug 16.


Nowadays the desire to look younger has increased. The most popular noninvasive rejuvenation method is hyaluronic acid (HA) filler injection. However, aging of the skin involves multiple pathological processes, which can be managed by using topical formulations with sophisticated active agents addressing problems such as extracellular matrix degradation, textural variances, and dyschromias. A single site experience trial was conducted to assess the efficacy of HA dermal filler injections combined with personally prepared, bespoke formulations on epidermis and dermis condition. A total of 15 female participated in the study. Mid and lower face were treated with Saypha® HA fillers injection with volume chosen by the investigator performed with 25G/50mm cannula. The formulations for topical skincare consisted of substances chosen from 19 active agents, which were scientifically proven. The subjects were supposed to use them for 6 weeks. Fourteen subjects completed the study, and one subject was lost to follow-up. The age of the study population ranged from 36 to 58 years. The average amounts of Saypha volume plus, Saypha volume, and Saypha filler used per subject were 2.8 ml, 2.25 ml and 1.7 ml, respectively. The most typical skin dysfunctions were loss of elasticity (12 subjects), hyperpigmentation (nine subjects), erythema (eight subjects), and hyperseborrhea with enlarged pores (five subjects). After completing the study all subjects were satisfied. Combined therapies based on HA fillers and personalized skincare with Universkin™ products show promising results in patients with skin problems due to aging.

Keywords: aesthetic medicine; antiaging; functional therapies; hyaluronic acid; personalized skincare.

MeSH terms

  • Adult
  • Cosmetic Techniques*
  • Dermal Fillers* / adverse effects
  • Esthetics
  • Female
  • Humans
  • Hyaluronic Acid / adverse effects
  • Middle Aged
  • Patient Satisfaction
  • Skin Aging*
  • Treatment Outcome


  • Dermal Fillers
  • Hyaluronic Acid