For the first time, at the early Ming Dynasty, the theoretical system of traditional Chinese medicine (TCM) are integrated with clinical diagnosis and treatment system in Yi Xue Gang Mu (An Outline of Medicine) written by LOU Ying. Under this unified theoretical framework, the integration of acupuncture prescription with herbal medicine formula is achieved, thus, a complete reconstruction of theoretic system of TCM is accomplished. Such reconstruction brings an extensive and profound impact on the development of medicine in the Ming and Qing dynasties, even influences implicitly the compilation of modern TCM textbooks. Through in-depth study of the theoretical innovation mode of An Outline of Medicine, the valuable revelation is provided for the inheritance and innovation of TCM in modern times.
明初楼英《医学纲目》首次将中医学理论体系与临床诊疗体系有机整合为一个统一体系，并在统一的理论框架下，实现了针方与药方的整合，完成了中医学理论体系一次完整的重构，对明清医学的发展产生了广泛而深远的影响，甚至潜移默化地影响了现代中医学教材的编撰。通过对楼英《医学纲目》理论创新模式的深入研究，可为今天中医学的守正创新提供极有价值的启示。.
Keywords: LOU Ying; Yi Xue Gang Mu (An Outline of Medicine); case study; theoretic innovation.