Post-incarceration outcomes for individuals who continued methadone treatment while in Connecticut jails, 2014-2018

Drug Alcohol Depend. 2021 Oct 1;227:108937. doi: 10.1016/j.drugalcdep.2021.108937. Epub 2021 Jul 28.


Purpose: To assess post-release outcomes associated with continuation of methadone treatment in correctional centers.

Methods: This case-control study of the post-incarceration impact of pilot methadone programs operating in jails in New Haven and Bridgeport, Connecticut, USA was conducted in 2014-18. The study compared non-fatal overdose, fatal overdose, reincarceration, and resumption of methadone in the community experienced by 1564 eligible men, 660 (42.2 %) of whom continued treatment while incarcerated.

Results: Continuation of methadone was associated with a significant decrease in non-fatal overdose (OR:0.55; 95 % CI: 0.36, 0.85) and a greater likelihood of resuming methadone treatment in the community post-release (OR:2.56; 95 % CI: 2.07, 3.16). Time to resumption of methadone was shortened by treatment while time to non-fatal overdose was increased. Treatment while incarcerated resulted in a modest but not significant decrease in fatal overdoses and no difference in reincarceration between those who did and did not receive methadone. However, resumption of methadone after release did significantly reduce fatal overdoses (OR = 0.26, 95 % CI: 0.11, 0.62, p = 0.002).

Conclusion and relevance: Improvements in post-release outcomes of non-fatal overdose and treatment reengagement emphasize the benefits of continuing medication-based treatment for opioid use disorder within the criminal justice system for those receiving it prior to being incarcerated.

Keywords: Correctional settings; Methadone; Opioid overdose; Opioid use disorder; Reincarceration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analgesics, Opioid / therapeutic use
  • Case-Control Studies
  • Connecticut / epidemiology
  • Drug Overdose* / drug therapy
  • Drug Overdose* / epidemiology
  • Humans
  • Jails
  • Male
  • Methadone / therapeutic use
  • Opiate Substitution Treatment
  • Opioid-Related Disorders* / drug therapy
  • Opioid-Related Disorders* / epidemiology
  • Prisoners*


  • Analgesics, Opioid
  • Methadone