First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency

Climacteric. 2021 Dec;24(6):624-628. doi: 10.1080/13697137.2021.1956453. Epub 2021 Aug 10.


Objective: This article reports the first case of pregnancy after frozen-thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China.

Methods: Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantation. Two years later, she showed complete remission from MDS, and six frozen-thawed ovarian tissue strips were transplanted into the peritoneal pocket.

Results: The patient's ovarian activity was restored 3 months after transplantation, and pregnancy occurred spontaneously 27 months after grafting. Until now, the pregnancy has progressed for 30 weeks, and the repeated ultrasound showed normal fetal development.

Conclusion: This is the first pregnancy resulting from ovarian tissue cryopreservation and transplantation in China.

Keywords: Ovarian tissue cryopreservation; pregnancy; premature ovarian insufficiency; transplantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • Female
  • Humans
  • Ovary*
  • Pregnancy*
  • Primary Ovarian Insufficiency*
  • Tissue Transplantation*