Distributed and centralized control during differentiation

Jonathan R Chubb; Hugh Z Ford; Vlatka Antolović

doi:10.1016/j.devcel.2021.07.007

Distributed and centralized control during differentiation

Dev Cell. 2021 Aug 9;56(15):2142-2144. doi: 10.1016/j.devcel.2021.07.007.

Authors

Jonathan R Chubb¹, Hugh Z Ford², Vlatka Antolović²

Affiliations

¹ MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: j.chubb@ucl.ac.uk.
² MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

PMID: 34375580
DOI: 10.1016/j.devcel.2021.07.007

Abstract

A persistent view of cell fate choices during development entails centralized control by so-called master regulators. A recent single-cell study of the large-scale fate specification during mammalian gastrulation (Mittnenzweig et al., 2021) implies the prevalence of more distributed forms of control.

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MeSH terms

Animals
Cell Differentiation
Gastrulation*