Smooth-talking T cells leave asthma breathless

Immunity. 2021 Aug 10;54(8):1623-1625. doi: 10.1016/j.immuni.2021.07.011.

Abstract

The plasma membrane channel PANX1 mediates release of bio-active adenine nucleotides; however, its function in immune cells is unknown. In this issue of Immunity, Medina et al. show that PANX1 mediates adenosine-dependent communication between regulatory and effector CD4+ T cells during allergic airway inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Asthma*
  • Connexins
  • Humans
  • Inflammation
  • Nerve Tissue Proteins
  • Respiratory System

Substances

  • Connexins
  • Nerve Tissue Proteins
  • PANX1 protein, human