Endoscopic Treatment as the Rescue Therapy for Recurrent Bleeding after Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Liyuan Ni; Xiaoquan Huang; Siyu Jiang; Lili Ma; Jianjun Luo; Shiyao Chen

doi:10.1155/2021/6627837

Endoscopic Treatment as the Rescue Therapy for Recurrent Bleeding after Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Gastroenterol Res Pract. 2021 Aug 2:2021:6627837. doi: 10.1155/2021/6627837. eCollection 2021.

Authors

Liyuan Ni¹, Xiaoquan Huang¹, Siyu Jiang¹, Lili Ma², Jianjun Luo³, Shiyao Chen^{1

2}

Affiliations

¹ Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
² Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
³ Department of Interventional Radiology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.

Abstract

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is suggested as the salvage therapy for gastroesophageal variceal bleeding in cirrhosis. However, rebleeding might occur in some patients after TIPS. Currently, there is a lack of evidence in the endoscopic management of recurrent bleeding in these patients.

Aims: To evaluate the efficacy of endoscopic treatment in cirrhotic patients with recurrent bleeding after TIPS.

Methods: Cirrhotic patients with gastroesophageal varices who received endoscopic treatment for recurrent bleeding after TIPS were included.

Results: 6 patients were enrolled in this study. The median age of the patients was 47 years (range 27 to 65 years), and the duration of follow-up time was 346 (17-773) days. Stent stenosis or occlusion was found in 5 out of 6 patients after TIPS. Salvage endoscopic treatment, including esophageal variceal ligation (EVL), gastric variceal cyanoacrylate injection, esophageal variceal sclerotherapy, and balloon-occluded retrograde transvenous obliteration- (BRTO-) assisted endoscopic cyanoacrylate injection. Among included patients, 2 died shortly after EVL (14 and 19 days) due to variceal bleeding. Among other 4 patients, 2 had rebleeding episodes at 422 and 789 days, respectively.

Conclusion: Endoscopic treatment may be an option for recurrent bleeding after TIPS in selected patients. Further studies are needed to carefully define the indication and efficacy of this option.