A late diagnosis of Pseudohypoaldosteronism type I in an infant with hypoplastic left heart syndrome presenting with failure to thrive

Cardiol Young. 2022 Mar;32(3):491-493. doi: 10.1017/S1047951121003127. Epub 2021 Aug 12.


Pseudohypoaldosteronism type I is caused by a peripheral resistance to aldosterone and can present with electrolyte abnormalities, poor growth, or dehydration. Although a rare disease, several case reports have been published regarding Pseudohypoaldosteronism type I in neonates and infants. We report a case of failure to thrive and hyponatremia in an infant with hypoplastic left heart syndrome who was subsequently found to have Pseudohypoaldosteronism type I.

Keywords: Pseudohypoaldosteronism; failure to thrive; hyponatraemia; hypoplastic left heart syndrome.

Publication types

  • Case Reports

MeSH terms

  • Delayed Diagnosis
  • Failure to Thrive / etiology
  • Humans
  • Hyponatremia* / complications
  • Hyponatremia* / diagnosis
  • Hypoplastic Left Heart Syndrome* / complications
  • Hypoplastic Left Heart Syndrome* / diagnosis
  • Infant
  • Infant, Newborn
  • Pseudohypoaldosteronism* / diagnosis
  • Pseudohypoaldosteronism* / etiology