Capsaicin and Its Effects on Body Weight

J Am Nutr Assoc. 2022 Nov-Dec;41(8):831-839. doi: 10.1080/07315724.2021.1962771. Epub 2021 Aug 12.


Capsaicin is a bioactive compound found in the fruits (i.e., peppers) of the plant genus Capsicum, which is widely used in many cultures. Besides many health effects of this compound, it can also be effective in body weight control through various mechanisms such as regulating lipolysis in adipocytes, increasing the feeling of satiety, stimulating energy expenditure, and reducing energy intake. This study investigated capsaicin and its effects on body weight control. In clinical studies, the amount of capsaicin affecting body weight loss differ. Longitudinal and randomized controlled studies are needed to explain the effects of capsaicin on body weight control.Key teaching points• Capsaicin can decrease hunger through hormones in the gastrointestinal tract.• Capsaicin can increase energy expenditure through brown adipose tissue.• Capsaicin can increase lipolysis in white adipose tissue.• More comprehensive studies are needed to clarify this issue.

Keywords: Capsaicin; Capsicum; bioactive component; obesity; pepper.

MeSH terms

  • Body Weight
  • Capsaicin* / pharmacology
  • Capsicum*
  • Energy Intake
  • Obesity / drug therapy


  • Capsaicin