Does caloric restriction prime the microbiome for pathogenic bacteria?

Cell Host Microbe. 2021 Aug 11;29(8):1209-1211. doi: 10.1016/j.chom.2021.07.009.

Abstract

A recent study in Nature finds significant shifts in the gut microbiome of post-menopausal women on severe calorie restriction concomitant with weight loss. Microbiota transplantation to germ-free mice display a similar weight loss, along with a bloom in C. difficile, unlocking clues to microbial metabolic alteration in weight loss.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / pathogenicity*
  • Caloric Restriction*
  • Clostridioides difficile
  • Fecal Microbiota Transplantation
  • Feces / microbiology
  • Gastrointestinal Microbiome*
  • Germ-Free Life
  • Humans
  • Mice
  • Obesity / microbiology
  • Weight Loss