Is there a relationship between sleep apnoea and microalbuminuria?

Sleep Breath. 2022 Sep;26(3):1459-1464. doi: 10.1007/s11325-021-02461-6. Epub 2021 Aug 13.


Introduction: Obstructive sleep apnoea (OSA) is a cause of hypoxia, and the correlation between hypoxia and microvascular complications is well known. Microalbuminuria (MAU) is a marker for endovascular dysfunction and an indicator of cardiovascular events and all-cause mortality in the general population. The aim of this study was to investigate the relationship between microvascular damage and the metabolic complications of OSA based on the presence of MAU.

Material and method: Urinary albumin/creatinine ratio (ACR) and microalbumin level were examined in patients with an apnoea-hypopnoea index (AHI) greater than 5/h (study group) and in patients with an AHI less than 5/h (control group). The exclusion criteria were other possible causes of MAU (hypertension, nephropathy, coronary artery disease, and severe thyroid dysfunction).

Results: Of 103 patients enrolled, 80 formed the group with OSA and 23 served as controls. According to the AHI values, the patients were divided into four groups as normal, mild, moderate and severe. There was no significant difference between the four groups in terms of the microalbumin level and urinary albumin/creatinine ratio.

Conclusion: In this study, no significant relationship was found between MAU and sleep apnoea.

Keywords: Endothelial damage; Microalbuminuria; Obstructive sleep apnoea; Polysomnography.

MeSH terms

  • Albumins
  • Albuminuria
  • Creatinine
  • Humans
  • Hypoxia
  • Polysomnography
  • Sleep Apnea Syndromes*
  • Sleep Apnea, Obstructive*


  • Albumins
  • Creatinine