CircadiOmic medicine and aging

Ageing Res Rev. 2021 Nov;71:101424. doi: 10.1016/j.arr.2021.101424. Epub 2021 Aug 11.


The earth displays daily, seasonal and annual environmental cycles that have led to evolutionarily adapted ultradian, circadian and infradian rhythmicities in the entire biosphere. All biological organisms must adapt to these cycles that synchronize the function of their circadiome. The objective of this review is to discuss the latest knowledge regarding the role of circadiomics in health and aging. The biological timekeepers are responsive to the environmental cues at microsecond to seasonal time-scales and act with precision of a clock machinery. The robustness of these rhythms is essential to normal daily function of cells, tissues and organs. Mis-alignment of circadian rhythms makes the individual prone to aging, sleep disorders, cancer, diabetes, and neuro-degenerative diseases. Circadian and CircadiOmic medicine are emerging fields that leverage our in-depth understanding of health issues, that arise as a result of disturbances in circadian rhythms, towards establishing better therapeutic approaches in personalized medicine and for geroprotection.

Keywords: Aging; Aging Clock; Circadian; Epigenetic Modifiers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Circadian Rhythm*